Consensus statement of the Russian Society of Obstetricians and Gynecologists and the Russian Association of Mammologists on the effect of combined oral contraceptives on breast tissue
Moscow, April 18, 2024
Сhairs: G.T. Sukhikh, V.N. Serov, N.I. Rozhkova
Experts: E.I. Abashova, N.V. Aganezova, E.N. Andreeva, I.I. Baranov, V.F. Bezhenar, Yu.E. Dobrokhotova, E.V. Enkova, L.Yu. Karakhalis, N.Yu. Katkova, T.A. Oboskalova, A.E. Protasova, T.M. Sokolova, L.S. Sotnikova, M.B. Stenina, N.I. Tapilskaya, M.B. Khamoshina, S.V. Yureneva, M.I. Yarmolinskaya
For citation: Consensus statement of the Russian Society of Obstetricians and Gynecologists and the Russian Association of Mammologists on the effect of combined oral contraceptives on breast tissue.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; 6: 177-181 (in Russian)
https://dx.doi.org/10.18565/aig.2024.148
References
- Министерство здравоохранения Российской Федерации. Клинические рекомендации. Доброкачественная дисплазия молочной железы. 2020. [Ministry of Health of the Russian Federation. Clinical guidelines. Benign breast dysplasia. 2020. (in Russian)].
- Министерство здравоохранения Российской Федерации. Клинические рекомендации. Рак молочной железы. 2021. [Ministry of Health of the Russian Federation. Clinical guidelines. Breast cancer. 2021. (in Russian)].
- Сухих Г.Т., Прилепская В.Н., ред. Национальные медицинские критерии приемлемости методов контрацепции. Адаптированный документ «Медицинские критерии приемлемости использования методов контрацепции ВОЗ, 5 издание, 2015». М.; 2023. [Sukhikh G.T., Prilepskaya V.N., ed. National medical acceptance criteria for contraceptive methods. Adapted from WHO Medical Acceptance Criteria for Contraceptive Use, 5th Edition, 2015. Moscow; 2023. (in Russian)].
- Burkman R.T. Oral contraceptives: current status. Clin. Obstet. Gynecol. 2001; 44(1): 62-72. https://dx.doi.org/10.1097/00003081-200103000-00010.
- Schindler A.E. Non-contraceptive benefits of oral hormonal contraceptives. Int. J. Endocrinol. Metab. 2013; 11(1): 41-7. https://dx.doi.org/10.5812/ijem.4158.
- Royal College of General Practitioners’ Oral Contraception Study. Effect on hypertension and benign breast disease of progestogen component in combined oral contraceptives. Effect on hypertension and benign breast disease of progestagen component in combined oral contraceptives. Lancet. 1977; 1(8012): 624.
- Brinton L.A., Vessey M.P., Flavel R., Yeates D. Risk factors for benign breast disease. Am. J. Epidemiol. 1981; 113(3): 203-14. https://dx.doi.org/10.1093/oxfordjournals.aje.a113089.
- Леонидова Т.Н., Микова В.Н. Гормональная контрацепция и маммологические риски. Доктор.Ру. 2016; 3(120): 15-7. [Leonidova T.N., Mikova V.N. Hormonal contraception and risks for breast disorders. Doctor.Ru. 2016; 3(120): 15-7. (in Russian)].
- Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies. Lancet. 1996; 347(9017): 1713-27. https://dx.doi.org/10.1016/s0140-6736(96)90806-5.
- Iversen L., Sivasubramaniam S., Lee A.J., Fielding S., Hannaford P.C. Lifetime cancer risk and combined oral contraceptives: the Royal College of General Practitioners’ Oral Contraception Study. Am. J. Obstet. Gynecol. 2017; 216(6): 580.e1-580.e9. https://dx.doi.org/10.1016/j.ajog.2017.02.002.
- Barańska A., Błaszczuk A., Kanadys W., Malm M., Drop K., Polz-Dacewicz M. Oral contraceptive use and breast cancer risk assessment: a systematic review and meta-analysis of case-control studies, 2009-2020. Cancers (Basel). 2021; 13(22): 5654. https://dx.doi.org/10.3390/cancers13225654.
- Адамян Л.В., Котова Е.Г., Родионов В.В., Протасова А.Э., Шешко Е.Л. Роль врача-гинеколога в выявлении патологии молочной железы и сочетанных гиперпролиферативных заболеваний. Проблемы репродукции. 2023; 29(5): 6-17. [Adamyan L.V., Kotova E.G., Rodionov V.V., Protasova A.E., Sheshko E.L. The role of the gynecologist in the detection of breast pathology and coexisting hyperproliferative diseases. Russian Journal of Human Reproduction. 2023; 29(5): 6-17. (in Russian)]. https://dx.doi.org/10.17116/repro2023290516.
- Gallez A., Dias Da Silva I., Wuidar V., Foidart J.M., Péqueux C. Estetrol and mammary gland: friends or foes? J. Mammary Gland Biol. Neoplasia. 2021; 26(3): 297-308. https://dx.doi.org/10.1007/s10911-021-09497-0.
- Schmidt M., Lenhard H., Hoenig A., Zimmerman Y., Krijgh J., Jansen M. et al. Tumor suppression, dose-limiting toxicity and wellbeing with the fetal estrogen estetrol in patients with advanced breast cancer. J. Cancer Res. Clin. Oncol. 2021; 147(6): 1833-42. https://dx.doi.org/10.1007/s00432-020-03472-8.
- Singer C.F., Bennink H.J., Natter C., Steurer S., Rudas M., Moinfar F. et al. Antiestrogenic effects of the fetal estrogen estetrol in women with estrogen-receptor positive early breast cancer. Carcinogenesis. 2014; 35(11): 2447-51. https://dx.doi.org/10.1093/carcin/bgu144.
- Инструкция по медицинскому применению препарата «Эстеретта». [Instructions for medical use of Esteretta. (in Russian)].
- Łukasiewicz S., Czeczelewski M., Forma A., Baj J., Sitarz R., Stanisławek A. Breast cancer-epidemiology, risk factors, classification, prognostic markers, and current treatment strategies-an updated review. Cancers (Basel). 2021; 13(17): 4287. https://dx.doi.org/10.3390/cancers13174287.
- Tamimi R.M., Spiegelman D., Smith-Warner S.A., Wang M., Pazaris M., Willett W.C. et al. Population Attributable Risk of modifiable and nonmodifiable breast cancer risk factors in postmenopausal breast cancer. Am. J. Epidemiol. 2016; 184(12): 884-93. https://dx.doi.org/10.1093/aje/kww145.
- WHO. Preventing cancer. https://www.who.int/activities/preventing-cancer (last access May, 2024).
- Stewart B.W., Bray F., Forman D., Ohgaki H., Straif K., Ullrich A. et al. Cancer prevention as part of precision medicine: ‘plenty to be done’. Carcinogenesis. 2016; 37(1): 2-9. https://dx.doi.org/10.1093/carcin/bgv166.
- Сметник А.А., Родионов В.В., Кометова В.В., Бурменская О.В., Дардык М.В., Сенча А.Н., Ермакова Е.И., Ашрафян Л.А. Молочная железа и половые гормоны. Акушерство и гинекология. 2021; 12: 58-66. [Smetnik A.A., Rodionov V.V., Kometova V.V., Burmenskaya O.V., Dardyk M.V., Sencha A.N., Ermakova E.I., Ashrafyan L.A. The breast and sex hormones. Obstetrics and Gynecology. 2021; (12): 58-66. (in Russian)]. https://dx.doi.org/10.18565/aig.2021.12.58-66.
About the Authors
Gennady T. Sukhikh, Dr. Med. Sci., Professor, First Vice-President of the Russian Society of Obstetricians and Gynecologists (RSOG), Merited Scholar of the Russian Federation, Director of the Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Academician of the Russian Academy of Sciences.Vladimir N. Serov, Dr. Med. Sci., Professor, President of the Russian Society of Obstetricians and Gynecologists (RSOG), Chief Researcher at the Department of Scientific and Educational Programs, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Academician of the Russian Academy of Sciences.
Nadezhda I. Rozhkova, Dr. Med. Sci., Professor, Merited Scholar of the Russian Federation, Laureate of the Prize of the Council of Ministers of the USSR, Head of the National Center for Oncology of the Reproductive Organs of the P.A. Herzen Moscow Research Oncological Institute – branch of the National Medical Research Center of Radiology, Ministry of Health of Russia, Professor of the Department of Clinical Mammology, Radiation Diagnostics and Radiation Therapy of the Faculty of Advanced Training of Medical Workers, Peoples' Friendship University of Russia, President of the Russian Association of Mammologists.
Elena I. Abashova, PhD, Senior Researcher at the Department of Gynecology and Endocrinology, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology.
Natalia V. Aganezova, Dr. Med. Sci., Professor, Department of Obstetrics and Gynecology, I.I. Mechnikov North-West State Medical University, Ministry of Health of Russia, Member of the Board of the European Society for Contraception and Reproductive Health (ESC).
Elena N. Andreeva, Dr. Med. Sci., Professor, Deputy Director – Director of the Institute of Reproductive Medicine, Professor at the Department of Clinical Endocrinology, Research Center of the National Medical Research Center of Endocrinology, Ministry of Health of Russia, Professor at the Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine, Ministry of Health of Russia, President of of International Association of Obstetricians, Gynecologists and Endocrinologists.
Igor I. Baranov, Dr. Med. Sci., Professor, Vice-President of the RSOG, Head of the Organizational and Methodological Department of the Scientific and Organizational Support Service, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
Vitaly F. Bezhenar, Dr. Med. Sci., Professor, Head of the Department of Obstetrics, Gynecology and Neonatology, I.P. Pavlov First St. Petersburg State Medical University, Ministry of Health of Russia, Chief Freelance Specialist Obstetrician-Gynecologist of the Health Committee of the Government of St. Petersburg.
Yulia E. Dobrokhotova, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, Faculty of Medicine, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia.
Elena V. Enkova, Dr. Med. Sci., Head of the Department of Obstetrics and Gynecology No. 2, N.N. Burdenko Voronezh State Medical University, Ministry of Health of Russia.
Lyudmila Yu. Karakhalis, Dr. Med. Sci., Professor, Professor at the Department of Obstetrics, Gynecology and Perinatology, Faculty of Advanced Studies and Professional Retraining of Specialists, Kuban State Medical University, Ministry of Health of Russia.
Nadezhda Yu. Katkova, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, Volga Research Medical University, Ministry of Health of Russia.
Tatyana A. Oboskalova, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology with a Course of Medical Genetics, Ural State Medical University, Ministry of Health of Russia.
Anna E. Protasova, Dr. Med. Sci., Professor, Professor at the Department of Oncology, St. Petersburg State University, Professor, Department of Obstetrics and Gynecology, V.A. Almazov National Medical Research Center, Ministry of Health of Russia, Chief Physician of the oncological clinic of AVA-PETER LLC.
Tatyana M. Sokolova, Dr. Med. Sci., Professor, Merited Doctor of the Russian Federation, Department of Obstetrics and Gynecology, Novosibirsk State Medical University, Ministry of Health of Russia.
Larisa S. Sotnikova, Dr. Med. Sci., Professor, Siberian State Medical University, Ministry of Health of Russia, obstetrician-gynecologist, endocrinologist, clinical pharmacologist, director of the Vozrozhdenie Scientific and Clinical Center for Hormonal Health, President of the Interregional Public Organization "Interdisciplinary Association of Anti-Aging Medicine Specialists" (IAAAMS).
Marina B. Stenina, Dr. Med. Sci., Leading Researcher at the Department of Anticancer Drug Therapy No. 1, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.
Natalya I. Tapilskaya, Dr. Med. Sci., Professor, Head of the Department of Reproductology, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Professor, Department of Obstetrics and Gynecology, St. Petersburg State Pediatric Medical University, Ministry of Health of Russia.
Marina B. Khamoshina, Dr. Med. Sci., Professor, Professor at the Department of Obstetrics and Gynecology with a course of perinatology, Medical Institute,
Peoples' Friendship University of Russia.
Svetlana V. Yureneva, Dr. Med. Sci., Professor, Leading Researcher at the Department of Gynecological Endocrinology, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Professor, Department of Obstetrics and Gynecology of the Department of Professional Education, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
Maria I. Yarmolinskaya, Professor of the Russian Academy of Sciences, Dr. Med. Sci., Professor, Head of the Department of Gynecology and Endocrinology,
D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Head of the Center for Innovative Methods of Diagnosis and Therapy of Endometriosis, Professor at the Department of Obstetrics and Gynecology, I.I. Mechnikov North-West State Medical University, Ministry of Health of Russia, President of the Society of Obstetricians and Gynecologists of St. Petersburg and the Northwestern Federal District.