Role of the vitamin K-dependent protein periostin in predicting the effectiveness of an assisted reproductive technology program

Khechumyan L.R., Kalinina E.A., Donnikov A.E., Kulakova E.V., Ibragimova E.O.

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia
Objective. To carry out a systematic analysis of the data available in the current literature on the role of the vitamin K-dependent protein periostin in the outcomes of an assisted reproductive technology (ART) program.
Material and methods. The review includes the data of foreign and Russian articles found in Pubmed on this topic.
Results. Investigations conducted in recent years provide evidence that periostin exerts an effect on some important steps in the implantation process. Due to a wide range of its functions, periostin is expressed in various organs and tissues. The follicular fluid and serum level of periostin can be correlated with oocyte quality indicators, embryo development, and pregnancy and live birth rates. The paper gives the data of an investigation of the vitamin K-dependent protein periostin as a non-invasive marker to predict oocyte and embryo qualities and pregnancy onset rates.
Conclusion. The investigations performed confirm that the use of periostin is promising and relevant in predicting the effectiveness of an ART program.

Keywords

assisted reproductive technology
infertility
periostin (POSTN)
in vitro fertilization
vitamin K
mRNA expression
embryo implantation

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Received 26.08.2016

Accepted 02.09.2016

About the Authors

Khechumyan Lusine Robertovna, graduate student of department of assisted reproductive technology in treatment of infertility, Research Center of Obstetrics,
Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina 4. Tel.: +74954382501. E-mail: khechumyan_l@mail.ru
Kalinina Elena Anatolievna, MD, Associate Professor, The chief of department of assisted reproductive technology in treatment of infertility, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina 4. Tel.: +74954381341. E-mail: e_kalinina@oparina4.ru
Donnikov Andrew Evgenievich, PhD, Senior Researcher of molecul-genetical laboratory, Research Center of Obstetrics, Gynecology, and Perinatology,
Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina 4. Tel.: +74954381341. E-mail: a_donnikov@oparina4.ru
Kulakova Elena Vladimirovna, PhD, Senior Researcher of department of assisted reproductive technology in treatment of infertility, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina 4. Tel.: +74954381341. E-mail: evkulakova@mail.ru
Ibragimova Espet Omarbekovna, graduate student of department of assisted reproductive technology in treatment of infertility, Research Center of Obstetrics,
Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina 4. Tel.: +74954382501. E-mail: Espet2007@yandex.ru

For citations: Khechumyan L.R., Kalinina E.A., Donnikov A.E., Kulakova E.V.,
Ibragimova E.O. Role of the vitamin K-dependent protein periostin in predicting
the effectiveness of an assisted reproductive technology program.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (7): 28-32. (in Russian)
http://dx.doi.org/10.18565/aig.2017.7.28-32

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