Risk for miscarriage and premature birth in women with HPV infection and recurrent vaginal dysbiosis

Bebneva T.N., Dikke G.B.

1 Peoples’ Friendship University of Russia, Ministry of Education and Science, Moscow, Russia; 2 F.I. Inozemtsev Academy of Medical Education, Saint Petersburg, Russia
Objective. To determine the rate and risk of miscarriage and preterm birth (PB) and to evalute the effect of progesterone in reducing the risk of PB in women with human papillomavirus (HPV) and recurrent dysbiosis.
Subjects and methods. The investigation enrolled 170 pregnant women (145 of them had HPV and recurrent vaginal dysbiosis). Group 1 (n = 36) took an antiseptic; Group 2 (n = 41) received an antiseptic and a probiotic. A control group (n = 25) had neither HPV nor dysbiosis. Sixty-eight patients used micronized progesterone. The strength of an association between variables (Cramer’s V coefficient) was analyzed.
Results. The rate of PB and late miscarriages was 24.7% and was strongly associated with the absence of effect of treatment for dysbiosis (VC = 0.7) and with the presence of recurrences (VC = 0.5). Micronized progesterone could reduce the rate of PB by 70% (OR = 0.3; 95% CI, 0.07-0.8; p = 0.02).
Conclusion. Pregnancy in the presence of HPV and recurrent dysbiosis is associated with a high risk of miscarriage and PB. The use of micronized progesterone reduces the rate of PB.


human papillomavirus
premature birth
spontaneous miscarriages


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Received 27.12.2018

Accepted 22.02.2019

About the Authors

Bebneva, Tamara N., PhD, associate professor, Department of Obstetrics, Gynecology and Reproductive Medicine, Faculty of Advanced Training for Medical Professionals
of the Medical Institute, Peoples’ Friendship University of Russia; doctor, National Medical Research Center of Endocrinology of the Ministry of Health of Russia.
117198, Russia, Moscow, Miklukho-Maklaya str. 21, bldg. 3.Tel.: +79165181964. E-mail: bebn@mail.ru. ORCID.org/0000-0003-1095-2008.
Dikke, Galina B., MD, associate professor, professor of the Department of Obstetrics and Gynecology with a course of reproductive medicine,
Private Educational Institution «Academy of Medical Education named F.I. Inozemtsev», St. Petersburg.
190013, Russia, St. Petersburg, Moscow Ave str. 22, letter M. Tel.: +78123347650. E-mail: galadikke@yandex.ru. ORCID.org 0000-0001-9524-8962.

For reference: Bebneva T.N., Dikke G.B. Risk for miscarriage and premature birth in women with HPV infection and recurrent vaginal dysbiosis. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (2): (in Russian)
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