Recurrent vaginitis: Diagnostic and treatment difficulties

Solovyeva A.V.

Peoples’ Friendship University of Russia, Ministry of Education and Science, Moscow 117198, Miklukho-Maklaya str. 8, Russia
Background. Recurrent vaginitides, lower urogenital tract diseases occurring at a frequency of 8-30%, are related to diagnostic and treatment difficulties.
Case report. The paper describes a case of a complex diagnosis of recurrent vaginal biotope disorder in the presence of premature ovarian failure in a 40-year-old woman with a Mirena intrauterine device. The use of intravaginal agents and systemic antibiotics was short-term effective.
Conclusion. After aerobic vaginitis, vulvovaginal candidiasis, and premature ovarian failure were diagnosed, the use of clindacin B prolong, ovipol clio led to the cessation of complaints and clinical manifestations of vaginal biotope disorders.


recurrent vaginitis
premature ovarian failure
clindacin B prolong
ovipol clio


1. Rakhmatulina M.R., Malova I.O., Sokolovsky E.V., Savicheva A.M., Apolikhina I.A., Melkumyan A.G. Federal clinical guidelines for management of patients with bacterial vaginosis. Moscow: Russian Society of Dermatovenerologists and Cosmetologists, Russian Society of Obstetricians and Gynecologists; 2015. Available at: (in Russian)

2. Management of vaginal discharge in non-genitourinary medicine settings. Clinical effectiveness unit. February 2012. Available at: GuidanceVaginal Discharge.pdf.

3. Donders G.G., Ruban K., Bellen G. Selecting anti-microbial treatment of aerobic vaginitis. Curr. Infect. Dis. Rep. 2015; 17(5): 477. doi: 10.1007/s 11908-015-0477-6.

4. Sobel J.D., Subramanian C., Foxman B., Fairfax M., Gygax S.E. Mixed vaginitis-more than coinfection and with therapeutic implications. Curr. Infect. Dis. Rep. 2013; 15(2): 104-8.

5. Castro J., Cerca N. BV and non-BV associated Gardnerella vaginalis establish similar synergistic interactions with other BV-associated microorganisms in dual-species biofilms. Anaerobe. 2015; 36: 56-9.

6. Eschenbach D.A. Chronic vulvovaginal candidiasis. N. Engl. J. Med. 2004; 351(9): 851-2.

7. Ravel J., Gajer P., Abdo Z., Schneider G.M., Koenig S.S., McCulle S.L. et al. Vaginal microbiome of reproductive-age women. Proc. Natl. Acad. Sci. USA. 2011; 108(Suppl. 1): 4680-7.

8. Brotman R.M., Bradford L.L., Conrad M., Gajer P., Ault K., Peralta L. et al. Association between Trichomonas vaginalis and vaginal bacterial community composition among reproductive-age women. Sex. Transm. Dis. 2012; 39(10): 807-12.

9. Melvin L., Glasier A., Elton R., Cameron S.T. pH-balanced tampons: do they effectively control vaginal pH? BJOG. 2008; 115(5):639-45.

10. Romero R., Hassan S.S., Gajer P., Tarca A.L., Fadrosh D.W., Nikita L. et al. The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women. Microbiome. 2014; 2(1): 4. doi: 10.1186/2049-2618-2-4.

11. Donders G.G. Definition and classification of abnormal vaginal flora. Best Pract. Res. Clin. Obstet. Gynaecol. 2007; 21(3): 355-73.

12. Donders G.G., Vereecken A., Bosmans E., Dekeersmaecker A., Salembier G., Spitz B. Definition of a type of abnormal vaginal flora that is distinct from bacterial vaginosis: aerobic vaginitis. BJOG. 2002; 109(1): 34-43.

13. Radzinsky V.E., ed. Non-developing pregnancy. Moscow: GEOTAR-Media; 2016. 176p. (in Russian)

14. Nyirjesy P. Management of persistent vaginitis. Obstet. Gynecol. 2014; 124(6): 1135-46.

15. Reichman O., Sobel J. Desquamative inflammatory vaginitis. Best Pract. Res. Clin. Obstet. Gynaecol. 2014; 28(7): 1042-50.

16. Fichorova R.N. Impact of T. vaginalis infection on innate immune responses and reproductive outcome. J. Reprod. Immunol. 2009; 83(1-2): 185-9.

Received 10.02.2017

Accepted 17.02.2017

About the Authors

Solovyeva Alina Viktorovna, Doctor of medicine, Professor the Department of Obstetrics and Gynecology with a Course of Perinatology, Peoples’ Friendship University
of Russia, Ministry of Education and Science. 117198, Russia, Moscow, Miklukho-Maklaya str. 8. Tel.: +79854477928. E-mail:

For citations: Solovyeva A.V. Recurrent vaginitis: Diagnostic and treatment difficulties. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (5): 152-5. (in Russian)
By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.