Prediction of the course of different types of pyelonephritis in pregnant women from innate immunity indicators
Objective. To investigate innate immunity indicators in pregnant women with different types of pyelonephritis.Seregin S.P., Petrov S.V., Kholimenko I.M.
Subjects and methods. A total of 200 pregnant women underwent an examination involving the identification of the clinical and anamnestic characteristics of the course of pregnancy, the laboratory diagnosis of inflammatory diseases, and the study of innate immunity indicators.
Results. The maximum content of complement C3 and C4 components was seen in a group of pregnant women with newly diagnosed pyelonephritis (36.3±2.07 and 58.3±4.0 ng/ml). The concentration of C1 (110.2±19.1 ng/ml) was decreased in a group of those with gestational pyelonephritis. The phagocytic indices (PI) (PI, 23.2±0.41%; phagocytic activity index (PAI), 1.02±0.03) were lower in a group of pregnant women with uncomplicated pyelonephritis than in a group of normal pregnancy (50.5±4.2 and 2.9±0.7).
Conclusion. The changes in immunity indices are more marked in patients with pyelonephritis first detected during pregnancy than in those with chronic pyelonephritis, in whom an exacerbation occurred during pregnancy.
Keywords
gestational pyelonephritis
phagocytosis
compliment system
Supplementary Materials
- Table 1. Indicators of the system complement in the study groups
- Table 2. Activity and intensity of phagocytosis of peripheral blood neutrophils
- Table 3. Activity of oxygen-dependent systems of peripheral blood neutrophils
References
1. Петров С.В., Серегин С.П., Кузьмин А.А., Кузьмина М.Н. Исследование цитокинового статуса при лечении серозного пиелонефрита во время беременности для систем принятия решений. Известия Юго-Западного государственного университета. 2012; 4-2: 56-60. [Petrov S.V., Seregin S.P., Kuzmin A.A., Kuzmina M.N. A study of the cytokine status in the treatment of serous pyelonephritis during pregnancy for decision-making systems. Izvestiya Yugo-Zapadnogo gosudarstvennogo universiteta. 2012; 4-2: 56-60. (in Russian)]
2. Хаитов Р.М., Игнатьева Г.А., Сидорович И.Г. Иммунология. Норма и патология. М.: Медицина; 2010. 752с. [Haitov R.M., Ignateva G.A., Sidorovich I.G. Immunology. Norm and pathology. Moscow: Meditsina; 2010. 752p. (in Russian)]
3. Гончарова Ю.М., Кузьменко В.В., Кузьменко А.В. Перспективные направления в лечении острого пиелонефрита. Вестник новых медицинских технологий. 2012; XIX(2): 291-5. [Goncharova Yu.M., Kuzmenko V.V., Kuzmenko A.V. Promising directions in the treatment of acute pyelonephritis. Vestnik novyih meditsinskih tehnologiy. 2012; XIX(2): 291-5. (in Russian)]
4. Дорошенко В.Э. Апоптоз в эндометрии у бесплодных женщин с комплексной неатипической гиперплазией (КНГЭ) в период окна имплантации. Таврический медико-биологический вестник. 2012; 1: 103-5. [Doroshenko V.E. Apoptosis in endometrium in infertile women with complex non-atypical hyperplasia during the implantation window. Tavricheskiy mediko-biologicheskiy vestnik. 2012; 1: 103-5. (in Russian)]
5. Havasi A., Borkan S.C. Apoptosis and acute kidney injury. Kidney Int. 2011; 80(1): 29-40.
6. Холименко И.М., Братчиков О.И., Джаримок А.Р., Шатохин М.Н., Маврин М.Ю., Быстрова Н.А. Лабораторная эффективность стандартного лечения при остром серозном и гнойном пиелонефрите. Курский научно-практический вестник «Человек и его здоровье». 2016; 1: 62-8. [Holimenko I.M., Bratchikov O.I., Dzharimok A.R., Shatohin M.N., Mavrin M.Yu., Byistrova N.A. Laboratory effectiveness of standard treatment for acute serous and purulent pyelonephritis. Kurskiy nauchno-prakticheskiy vestnik «Chelovek i ego zdorove». 2016; 1: 62-8. (in Russian)]
7. Мурзалиев А.Д. Иммунологические показатели у больных с острым пиелонефритом. Вестник Кыргызско-Российского славянского университета. 2015; 7(15): 112-4. [Murzaliev A.D. Immunological indicators in patients with acute pyelonephritis. Vestnik Kyirgyizsko-Rossiyskogo slavyanskogo universiteta. 2015; 7(15): 112-4. (in Russian)]
8. Шатохин М.Н., Холименко И.М., Джаримок А.Р., Маврин М.Ю., Конопля Н.А., Чирков С.В. Состояние врожденного иммунитета до и после комплексного лечения при остром пиелонефрите. Иммунопатология, аллергология, инфектология. 2016; 1. 57-63. [Shatohin M.N., Holimenko I.M., Dzharimok A.R., Mavrin M.Yu., Konoplya N.A., Chirkov S.V. Condition of congenital immunity before and after complex treatment for acute pyelonephritis. Immunopatologiya, allergologiya, infektologiya. 2016; 1. 57-63. (in Russian)]
9. Снопков В.Н., Бурмакова А.А., Гонтарев С.Н., Иванов В.А. Прогностическая значимость показателей системного иммунитета при почечной патологии. Научные ведомости Белгородского государственного университета. Серия: Медицина. Фармация. 2013; 154(11): 222-5. [Snopkov V.N., Burmakova A.A., Gontarev S.N., Ivanov V.A. Prognostic significance of indices of systemic immunity in renal pathology. Scientific bulletins of the Belgorod State University. Series: Medicine. Pharmacy. 2013; 154(11): 222-5. (in Russian)]
10. Калинина Н.И., Сысоева В.Ю., Рубина К.А., Парфенова Е.В., Ткачук В.А. Мезенхимальные стволовые клетки в процессах роста и репарации тканей. Acta Naturae (русскоязычная версия). 2011; 4. 32-9. [Kalinina N.I., Syisoeva V.Yu., Rubina K.A., Parfenova E.V., Tkachuk V.A. Mesenchymal stem cells in the processes of tissue growth and repair. Acta Naturae (Russian version). 2011; 4. 32-9. (in Russian)]
11. Никуличева В.И., Сафуанова Г.Ш., Карпина Н.С. Иммуновоспалительные маркеры хронического пиелонефрита. Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук. 2014; 95(1): 45-9. [Nikulicheva V.I., Safuanova G.Sh., Karpina N.S. Immunosuppressive markers of chronic pyelonephritis. Bulletin of the East Siberian Scientific Center of the Siberian Branch of the Russian Academy of Medical Sciences. 2014; 95(1): 45-9. (in Russian)]
12. Глыбочко П.В., Аляев Ю.Г. Интегративная урология. Руководство для врачей. М.: Медфорум; 2014. 432с. [Glybochko PV, Alyaev Yu.G. Integrative urology. A guide for doctors. Мoscow: Medforum; 2014. 432p. (in Russian)]
Received 09.03.2017
Accepted 28.04.2017
About the Authors
Seryogin Stanislav Petrovitch, Prof., MD, Department of Biomedical Engineering, South-Western State University, Ministry of Education and Science of Russia.305040, Russia, Kursk, 50 years of October str. 94. Tel.: +79102154354. E -mail: seregin.stanislaw2011@yandex.ru
Petrov Sergey Vyacheslavovich, PhD, Gynecologist, Kursk City Hospital Six. 305044, Russia, Kursk, Soyuznaya str. 30. Tel.: +79102184859. E-mail: spetrov77@list.ru
Kholimenko Ivan Mihajlovich, Urologist, Kursk City Clinical Hospital of Emergency Medical Care.
305000, Russia, Kursk, Pirogova str. 14. Tel.: +79202698357. E-mail: kholimenko@yandex.ru
For citations: Seregin S.P., Petrov S.V., Kholimenko I.M. Prediction of the course of different types of pyelonephritis in pregnant women from innate immunity indicators. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (1): 48-52. (in Russian)
https://dx.doi.org/10.18565/aig.2018.1.48-52
