Characteristics of metastatic lobular breast cancer

Filonenko D.A., Ganshina I.P., Kondratyeva O.E., Borisova E.I., Gordeeva O.O., Gutorov S.L., Vyshinskaya G.V., Kolyadina I.V., Khokhlova S.V., Malikhova O.A., Kuvshinov Yu.P., Vishnevskaya Ya.V., Morozov D.A., Meshcheryakov A.A.

1) N.N. Blokhin National Medical Center of Oncology, Ministry of Health of Russia, Moscow, Russia; 2) Department of Oncology and Palliative Medicine, Russian Medical Academy of Continuing Professional Education, Moscow, Russia; 3) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
Background. Lobular breast cancer (BC) occurs in 10-15% of BC cases and more frequently than ductal one, it metastasizes to the gastrointestinal organs.
Case report. The authors present their own experience in treating patients with metastases to various segments of the gastrointestinal tract.
Conclusion. The localization of metastases in the organs of the gastrointestinal tract calls for a differential diagnosis of a primary gastrointestinal tract tumor from metastatic lobular cancer; the diagnosis of lobular cancer requires additional examination of the organs of the gastrointestinal tract for the early detection of metastatic lesions and the prevention of complications.

Keywords

lobular breast cancer
gastrointestinal metastases

References

  1. Ellis IO, Schnitt SJ, Sastre-Garau X, et al. Invasive Breast Carcinoma. In: Tavassoli FA, Devilee P., eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of the Breast and Female Genital Organs. Lyon, France: IARC Press; 2003: 23-26
  2. Pestalozzi, B.C., Zahrieh, D., Mallon, E., Gusterson, B. A., Price, K. N., Gelber, R.D., Goldhirsch, A. Distinct clinical and prognostic features of infiltrating lobular carcinoma of the breast: Combined results of 15 International Breast Cancer Study Group clinical trials. J. Clin.Oncol. 2008; 26(18): 3006–14. https://doi.org/10.1200/JCO.2007.14.9336
  3. Borroso-Sousa R., Fliho O. Differences between invasive lobular and invasive ductal carcinoma of the breast: results and therapeutic implications. Ther Adv Med. Oncol. 2016; 8(4): 261–6. doi:10.1177/1758834016644156
  4. Arpino G, Bardou V, Clark G, Elledge R. Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome. Breast Cancer Res. 2004; 6(3):R149–56. DOI: 10.1186/bcr767
  5. Борисова Е.И., Вышинская Г.В., Гуторов С.Л., Степанченко М.В. Особенности клинического течения инвазивного долькового рака молочной железы. Фарматека, 2014; 17: 38–42.[Borisova E.I., Vyshinskaya G.V., Gutorov S.L., Stepanchenko M.V. Clinical features of invasive lobular breast cancer. Farmateka. 2014; 17: 38–42.(In Russian)].
  6. Namikawa T, Hanazaki K. Clinicopathological features and treatment outcomes of metastatic tumors in the stomach. Surg. Today. 2014; 44:1392–9. doi:10.1007/s00595-013-0671-9
  7. Borst M.J., Ingold J.A. Metastatic patterns of invasive lobular versus invasive ductal carcinoma of the breast. Surgery. 1993;114: 637–41; discussion 641–2. https://doi.org/10.1007/s10549-013-2493-2
  8. Mathew A., Rajagopal P., et al: Distinct Pattern of Metastases in Patients with Invasive Lobular Carcinoma of the Breast. Geburtshilfe Frauenheilkd. 2017 Jun; 77(6): 660–6. https://doi.org/10.1007/s10549-013-2493-2
  9. Switzer N., Lim A., Du L., Al-Sairafi R., Tonkin K., Shiller D. Case series of 21 patients with extrahepatic metastatic lobular breast carcinoma to the gastrointestinal tract. Cancer treatment Communications. 2015; 3 (9, Suppl.): 37–43. https://doi.org/10.1016/j.ctrc.2014.11.006
  10. Мontagna E., Pirola S., Maisonneuve P., Roberto G., Palazzo A., Viale G., Colleoni M. Lobular Metastatic Breast Cancer Patients With Gastrointestinal Involvement: Features and Outcomes. Clin. Breast Cancer. 2018; 18(3): e401–e405. DOI: 10.1016/j.clbc.2017.07.003
  11. Колядина И.В., Абдуллаев А.Г., Танишина Н.Б., Перфильев И.Б., Долгушин М.Б., Оджарова А.А., Козлов Н.А., Ганьшина И.П., Чистякова О.В., Поддубная И.В., Павликова О.А. Мультимодальный подход к дифференциальной диагностике метастатического поражения при раке молочной железы:описание клинического случая. Злокачественные опухоли. 2017. 7(3): 31-36.[Kolyadina I.V., Abdullaev A.G., Tanishina N.B., Perfiliev I.B., Dolgushin M.B., Odzharova A.A., Kozlov N.A., Ganshina I.P., Chistyakova O.V., Poddubnaya I.V., Pavlikova O.A. Multimodal approach to differential diagnosis of breast cancer metastatic lesions: case report. Malignant tumours. 2017; 7(3): 31–6. (In Russ.)]. https://doi.org/10.18027/2224-5057-2017-3-31-36
  12. Колядина И.В., Ганьшина И.П., Жукова Л.Г., Абдуллаев А.Г., Андреева Ю.Ю., Данзанова Т.Ю., Синюкова Г.Т., Комов Д.В., Козлов Н.А., Филоненко Д.А., Гордеева О.О., Лубенникова Е.В. Метастатическое поражение мягких тканей ягодичной области при her2+ раке молочной железы: описание клинического случая. Современная онкология. 2017. 19(4): 36-38.[Kolyadina I.V., Ganshina I.P., Zhukova L.G., Abdullaev A.G. Andreeva Yu.Yu., Danzanova T.Yu., Sinyukova G.T., Komov D.V., Kozlov N.A., Filonenko D.A., Gordeeva O.O., Lubennikova E.V. Soft tissue metastases of the gluteal region in HER2+ breast cancer: a clinical case. Sovremennaja onkologija. 2017. 19(4): 36-38. (In Russ.)]. eLIBRARY ID: 32210887
  13. Amin A.A., Reddy A., Jha M., Prasad K. Rectal metastasis from breast cancer: an interval of 17 years. BMJ Case Rep. 2011; 2011.pii:bcr01020113683. doi:10.1136/bcr.01.2011.3683.
  14. Yoshida Y. Metastases and primary neoplasms of the stomach in patients with breast cancer. Am. J. Surg. 1973; 125(6): 738–43. doi:10.1016/0002-9610(73)90176-1
  15. Xu L., Liang S., et al. Metastatic gastric cancer from breast carcinoma: A report of 78 cases. Oncol. Lett. 2017; 14(4): 4069–77. doi: 10.3892/ol.2017.6703
  16. Ambroggi M., Stroppa E.M., et al. Metastatic Breast Cancer to the Gastrointestinal Tract: Report of Five Cases and Review of the Literature. Int. J. Breast Cancer. 2012;ID439023. doi:10.1155/2012/439023
  17. Yagi Y., Sasaki S., et al. Metastatic gastric carcinoma from breast cancer mimicking primary linitis plastica: A case report. Oncol. Lett. 2015; 10(6): 3483–7. doi:10.3892/ol.2015.3788

Received 15.03.2019

Accepted 19.04.2019

About the Authors

Daria A. Filonenko, PhD, oncologist, chemotherapy department and combined methods of treatment of malignant tumors, Federal State Budgetary Institution
«N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation, e-mail shubina_d@mail.ru, phone: +79032130568. 115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Inna P. Ganshina, PhD, oncologist, chemotherapy department and combined methods of treatment of malignant tumors, Federal State Budgetary Institution
«N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation , e-mail: ganshinainna77@mail.ru, phone: +79266505419. 115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Oxana E.Kondratieva, oncologist, chemotherapy department and combined methods of treatment of malignant tumors, Federal State Budgetary Institution
«N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation, e-mail: ksanakondratyevad@yandex.ru, phone: phone: +79161295752. 115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Elena I. Borisova, PhD, oncologist, chemotherapy department and combined methods of treatment of malignant tumors, Federal State Budgetary Institution
«N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation, e-mail: doctorborisova@ya.ru, phone: +79031991939. 115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Olga O. Gordeeva, oncologist, chemotherapy department and combined methods of treatment of malignant tumors, Federal State Budgetary Institution
«N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation, e-mail: helga.stolz@yandex.ru, phone: +79257289986. 115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Sergey L. Gutorov, MD, oncologist, chemotherapy department and combined methods of treatment of malignant tumors, Federal State Budgetary Institution
«N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation,
s1gutorov@gmail.com, phone: +79031990606; 115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Galina V. Vishinskaya, MD, oncologist, chemotherapy department and combined methods of treatment of malignant tumors, Federal State Budgetary Institution
«N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation, galina@userhost.ru , phone: +79250299641.
115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Irina V. Kolyadina, MD, oncologist Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuous Professional Education” of the Ministry of Healthcare of the Russian Federation, phone: +79067926694, e-mail: irinakolyadina2014@gmail.com;
117997 Russian Federation, Moscow, Ac. Oparina Street, 4.
Svetlana V. Hohlova, MD, Head of the Oncology Department of Anticancer Drug Therapy, Academician V.I. Academician V.I. Kulakova; 8 (495) 531-44-44;
117997 Russian Federation, Moscow, Ac. Oparina Street, 4.
Olga A. Malikhova, MD, oncologist, head of the endoscopy department, Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology»
оf the Ministry of Health of the Russian Federation, phone: +9031990612, e-mail: malikhova@inbox.ru; 115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Yurii P. Kuvshinov, MD, oncologist, endoscopy department, Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology»
оf the Ministry of Health of the Russian Federation, phone: +79031991883; 115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Yana V. Vishnevskaya , PhD, oncologist, pathology department, Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology»
оf the Ministry of Health of the Russian Federation, phone: +9161417563, yana_vishn@list.ru; 115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Dmitrii A. Morozov, oncologist, Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuous Professional Education” of the Ministry of Healthcare of the Russian Federation, phone:+79999808569, e-mail: emulator2008@rambler.ru;
125993 Russian Federation, Moscow, Barrikadnaya street 2/1.
Andrey A. Meshcheryakov, MD, head of chemotherapy department and combined methods of treatment of malignant tumors, Federal State Budgetary Institution
«N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation, phone: +79265361007, a_meshcheryakov@mail.ru; 115478 Russian Federation, Moscow, Kashirskoe sh., 23.

Financing. The investigation has not been supported.For citation: Filonenko D.A., Ganshina I.P., Kondratyeva O.E., Borisova E.I., Gordeeva O.O., Gutorov S.L., Vyshinskaya G.V., Kolyadina I.V., Khokhlova S.V., Malikhova O.A., Kuvshinov Yu.P., Vishnevskaya Ya.V., Morozov D.A., Meshcheryakov A.A. Characteristics of metastatic lobular breast cancer.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (10): 180-87. (in Russian).
http://dx.doi.org/10.18565/aig.2019.10.180-187
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