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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2020№5
Perinatal outcomes of twin pregnancies...

Perinatal outcomes of twin pregnancies with birth weight discordance

DOI
https://dx.doi.org/10.18565/aig.2020.5.78-84

Kostyukov K.V., Ionov O.V., Shakaya M.N.

1) V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia, Moscow, Russia; 2) I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia (Sechenov University), Moscow, Russia
Birth weight discordance in multiple pregnancies is not uncommon, and significant birth weight difference is a risk factor for adverse outcomes. Aim. To investigate perinatal outcomes of twin pregnancies with significant (over 25%) birth weight discordance. Material and methods. The study comprised 485 pregnant women and their 959 newborns. Two groups were formed based on the presence or absence of birth weight discordance, in which the antenatal and neonatal periods were analyzed. Results. Birth weight discordance was detected in 18.8% of twins. The antenatal mortality rate in groups with and without birth weight discordance was 6.6% and 1.3%, respectively, p = 0.008. The median gestational age of twins with and without birth weight discordance was 33.6 and 36.0 weeks, respectively, p <0.001. Twins with birth weight discordance had significantly lower birth weight (1654 g) than concordant twins (2386 g), p <0.001. The neonatal mortality rate of twins with birth weight discordance was 9.1% compared with 1% in concordant twins, p <0.001. Discordant twins had higher neonatal morbidity (21.6%) than concordant twins (6.1%), (p = 0.002). Conclusion. Twin birth weight discordance is a risk factor for antenatal death, premature birth, and surgical delivery. At the same time, birth weight discordance is associated with high neonatal morbidity (respiratory and neurological disorders) and mortality.

Keywords

multiple gestation pregnancy
fetal growth restriction of one twin
birth weight discordance
Full text (in Russian)

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Received 28.11.2019

Accepted 29.11.2019

About the Authors

Kirill V. Kostyukov, Ph.D., Senior Researcher at the Department of Fetal Medicine, Institute of Obstetrics; Physician at the Department of Functional and Ultrasound Diagnostics, Department of Diagnostic Imaging, V.I. Kulakov NMRC for OG&P of Minzdrav of Russia. Tel.: +7(926)214-97-84. E-mail: kostyukov_k@yahoo.com.
4 Oparina str., Moscow, 117997, Russian Federation
Oleg V. Ionov, Ph.D., Head of the A.G. Antonov Neonatal Intensive Care Unit, Institute of Neonatology and Pediatrics, V.I. Kulakov NMRC for OG&P of Minzdrav of Russia; Associate Professor at the Department of Neonatology, Faculty of Pediatrics of I.M. Sechenov First MSMU. E-mail: o_ionov@oparina4.ru.
4 Oparina str., Moscow, 117997, Russian Federation.
Marika N Shakaya, Ph.D., Teaching Assistant at the Department of Neonatology, N.F. Filatov Clinical Institute of Children’s Health, I.M. Sechenov First MSMU of Minzdrav
of Russia (Sechenov University); Emergency Neonatologist at the A.G. Antonov Neonatal Intensive Care Unit, Institute of Neonatology and Pediatrics, V.I. Kulakov
NMRC for OG&P of Minzdrav of Russia; Tel.: +7(903)769-61-60. E-mail: m_shakaya@oparina4.ru. 4 Oparina str., Moscow, 117997, Russian Federation.

For citation: Kostyukov K.V., Ionov O.V., Shakaya M.N.
Perinatal outcomes of twin pregnancies with birth weight discordance.
Akusherstvo i Ginekologiya/Obstetrics and gynecology. 2020; 5: 78-84 (In Russian).
https://dx.doi.org/10.18565/aig.2020.5.78-84
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