Evaluation of the clinical efficiency of antiviral therapy for recurrent genital herpes
Objective. To evaluate the efficacy of Valvir (valacyclovir) in the treatment of patients with recurrent genital herpes.Pestrikova T.Yu., Yurasova E.A., Kovaleva T.D., Voronova Yu.V., Kotelnikova A.V.
Subjects and methods. The study covered 34 patients aged from 18 to 35 years, in whom the diagnosis of recurrent genital herpes was verified according to clinical and laboratory findings. The clinical efficiency of antiviral therapy was evaluated in the patients during 3 gynecology visits.
Results. The findings suggest that disappearance of herpetic rashes and healing of focal lesions occurred with a high degree of statistical significance on day 4 of treatment. The area of affected foci with residual phenomena of herpetic rashes was decreased by 75% or more of the initial value at follow-up day 6. The duration of a recurrent genital herpes episode was reduced by 1.67 times.
Conclusion. The episodic use of Valvir (valacyclovir) in patients with recurrent genital herpes can statistically significantly reduce the severity and duration of the current relapse and provide psychological support for the patients.
Keywords
recurrent genital herpes
Valvir (valacyclovir)
Supplementary Materials
References
1. Мацца Д. Справочник по гинекологии. Пер. с англ. Сухих Г.Т., Аполихина И.А., ред. М.: Практическая медицина; 2017. 568с. [Mazza D. Handbook of gynecology. Trans. from English. Sukhikh G.T., Apolikhina I.A., ed. Moscow: Practical medicine; 2017. 568р. (in Russian)]
2. Федеральные клинические рекомендации по ведению больных с генитальным герпесом. М.; 2015. 13с. [Federal clinical practice guidelines for the management of patients with genital herpes. Moscow; 2015. 13р. (in Russian)]
3. Paladino P., Mossman K.L. Mechanisms employed by herpes simplex virus 1 to inhibit the interferon response. J. Interferon Cytokine Res. 2009; 29(9): 599-608. doi: 10.1089/jir.2009.0074.
4. Stanberry L.R. Genital and perinatal herpes simplex virus infections. In: Stanberry L., Rosenthal S., eds. Sexually transmitted diseases. Vaccines, prevention and control. Academic Press; 2013; 273-313. doi: 10.1016/b978-0-12-391059-2.00012-7.
5. Пестрикова Т.Ю., Юрасов И.В., Юрасова Е.А. Воспалительные заболевания в гинекологии. Практическое руководство. М.: Литтерра; 2009. 256с. [Pestrikova T.Y., Yurasov I.V., Yurasova E.A. Inflammatory diseases in gynecology: a practical guide. M.: Litterra; 2009. 256p. (in Russian)]
6. Cao S., Gan Y., Dong X., Lu Z. Herpes simplex virus type 2 and the risk of cervical cancer: a meta-analysis of observational studies. Arch. Gynecol. Obstet. 2014; 290(6): 1059-66. doi: 10.1007/s00404-014-3365-7.
7. Vergou T. Herpes simplex virus infection (Orofacial). In: Katsambas A., Lotti T., Dessinioti C., D’Erme A.M., eds. European handbook of dermatological treatments. Springer; 2015: 373-7. doi: 10.1007/978-3-662-45139-7_38.
8. Саразитдинова В.Ф. Наиболее распространенные вирусные инфекции, передаваемые половым путем (герпетическая, папилломавирусная, цитомегаловирусная). Клиническая дерматология и венерология. 2011; 3: 82-7. [Sirazetdinov V.F. The most common viral infections, sexually transmitted diseases (herpes, human papillomavirus, cytomegalovirus). Klinicheskaya dermatologiya i venerologiya/Clinical dermatology and venereology. 2011; 3: 82-7. (in Russian)]
9. Петерсен Э.Э. Инфекции в акушерстве и гинекологии. Пер. с англ. Прилепская В.Н., ред. М.: МЕДпресс-информ; 2007. 352с. [Petersen E.E. Infections in obstetrics and gynecology. Trans. from English. Prilepskaya V.N., eds. Moscow: MEDpress-inform, 2007. 352p. (in Russian)]
10. Abudalu M., Tyring S., Koltun W., Bodsworth N., Hamed K. Single-day, patient-initiated famciclovir therapy versus 3-day valaciclovir regimen for recurrent genital herpes: a randomized, double-blind, comparative trial. Clin. Infect. Dis. 2008; 47(5): 651-8. doi: 10.1086/590561.
11. Pinder M., Wright A. Valaciclovir versus aciclovir for the treatment of primary genital herpes simplex: a cost analysis. Int. J. STD & AIDS. 2014; 26(13): 971-3. doi: 10.1177/0956462414563628.
12. Шульженко А.Е., Зуйкова И.Н. Психосоциальные аспекты генитальной герпес-вирусной инфекции. Российский журнал кожных и венерических болезней. Приложение: Герпес. 2007; 1: 13-8. [Shulzhenko A.E., Zuikova I.N. Psychosocial aspects of genital herpes virus infection. Rosciiskii zhurnal kozhnykh i venericheskikh boleznei/ROS. jour. coin. and veins. diseases. Application: Herpes. 2007. 2007; 1: 13-18. (in Russian)]
Received 16.06.2017
Accepted 23.06.2017
About the Authors
Pestrikova Tatyana Yurievna, MD, professor, head of the Department of Obstetrics and Gynecology, Far Eastern State Medical University, Ministry of Health of Russia. 680000, Russia, Khabarovsk, Muravyeva-Amurskogo str. 35. Tel.: +74212305311, +79147719383. E-mail: typ50@rambler.ruYurasova Elena Anatolyevna, MD, Professor of the Department of Obstetrics and Gynecology, Far Eastern State Medical University, Ministry of Health of Russia.
680000, Russia, Khabarovsk, Muravyeva-Amurskogo str. 35. Tel.: +74212305311, +79625838255. E-mail: urasovaea@yandex.ru
Kovaleva Tamara Daniilovna, MD, Assistant of the Department of Obstetrics and Gynecology, Far Eastern State Medical University, Ministry of Health of Russia.
680000, Russia, Khabarovsk, Muravyeva-Amurskogo str. 35. Tel.: +79242120730. E-mail: kov-express@mail.ru
Voronova Yulia Vladimirovna, MD, associate professor of the Department of Obstetrics and Gynecology, Far Eastern State Medical University, Ministry of Health of Russia. 680000, Russia, Khabarovsk, Muravyeva-Amurskogo str. 35. Tel.: +79098411288. E-mail: yulyapankova @ rambler.ru
Kotelnikova Anastasia Vladimirovna, Assistant of the Department of Obstetrics and Gynecology, Far Eastern State Medical University, Ministry of Health of Russia.
680000, Russia, Khabarovsk, Muravyeva-Amurskogo str. 35. Tel.: +74212305311, +79145407860. E-mail: tempo-m@mail.ru
For citations: Pestrikova T.Yu., Yurasova E.A., Kovaleva T.D., Voronova Yu.V., Kotelnikova A.V. Evaluation of the clinical efficiency of antiviral therapy for recurrent genital herpes. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (9): 127-31. (in Russian)
http://dx.doi.org/10.18565/aig.2017.9.127-31
