Metastatic brain involvement in genital cancer
Objective. To analyze a group of patients with brain metastases from genital cancer.Nerodo G.A., Vladimirova L.Yu., Mitashok I.S., Kalabanova E.A., Rostorguev E.E.
Material and methods. From 2002 to 2016, the investigators followed up 26 patients aged 25 to 74 years who had brain metastases from genital cancer.
Results. Brain metastases occurred more frequently in patients with ovarian malignancies, then in those with uterine corpus and cervical cancer. The shortest time from primary tumor detection to diagnosis of brain metastases was 1 month in a patient with chorion carcinoma; that averaged 27.5 months in those with ovarian malignancies, 34.2 and 41 months in those with uterine corpus and cervical cancer, respectively.
Conclusion. Metastatic brain involvement has clinical features that should be taken into account in the clinical and laboratory diagnosis for the early detection of brain metastases and subsequent treatment.
Keywords
genital cancer
brain metastases
metastatic latency
References
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Received 07.06.2017
Accepted 23.06.2017
About the Authors
Nerodo Galina Andreevna, MD, PhD, Professor, corresponding member of RAS, chief researcher, Rostov Research Institute of Oncology, Ministry of Health of Russia.344037, Russia, Rostov-on-Don, 14-ya liniya str. 63. Tel.: +78633000200. E-mail: rnioi@list.ru
Vladimirova Liubov Yurievna, MD, PhD, Professor, Head of Department of Drug Therapy No.1, Rostov Research Institute of Oncology, Ministry of Health of Russia.
344037, Russia, Rostov-on-Don, 14-ya liniya str. 63. Tel.: +78633000200. E-mail: vlu@aaanet.tu
Mitashok Irina Stepanovna, Head of Department of Drug Therapy No.2, Rostov Research Institute of Oncology, Ministry of Health of Russia.
344037, Russia, Rostov-on-Don, 14-ya liniya str. 63. Tel.: +78633000200. E-mail: imitashok@mail.ru
Kalabanova Elena Aleksandrovna, MD, PhD, senior researcher, Rostov Research Institute of Oncology, Ministry of Health of Russia.
344037, Russia, Rostov-on-Don, 14-ya liniya str. 63. Tel.: +78633000200. E-mail: alenakalabanova@mail.ru
Rostorguev Eduard Evgenievich, MD, PhD, Head of Department of Neurooncology, Rostov Research Institute of Oncology, Ministry of Health of Russia.
344037, Russia, Rostov-on-Don, 14-ya liniya str. 63. Tel.: +78633000200. E-mail: ed.rost@mail.ru
For citations: Nerodo G.A., Vladimirova L.Yu., Mitashok I.S., Kalabanova E.A., Rostorguev E.E. Metastatic brain involvement in genital cancer. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (1): 96-101. (in Russian)
https://dx.doi.org/10.18565/aig.2018.1.96-101
