Diagnosis of vulvar condyloma acuminatum: clinical and molecular genetic aspects

Apolikhina I.A., Gasanova G.F., Trofimov D.M., Donnikov A.E.

1) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia; 2) Department of Obstetrics, Gynecology, Perinatology, and Reproductology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia
Objective. To optimize the diagnosis of vulvar condyloma acuminatum (CA), by expanding the possibilities of using the polymerase chain reaction (PCR) in clinical practice.
Subjects and methods. Ninety patients with vulvar CA were examined. All the examined women underwent vulvoscopy with a vinegar test, high-frequency ultrasound of the skin and vulvar mucosa, human papillomavirus (HPV) typing in the samples of the cervical canal epithelium, scrapes from CA, and its biopsy specimens. Biopsies (n = 90) were performed in AC measuring more than 3 mm in diameter.
Result. Analyzing the identification of HPV types revealed that HPV 6 and HPV 44 were statistically significantly more common in the biopsy specimens of CA than in those of the cervical canal and in the CA scrapes; HPV 11 was found statistically significantly more frequently in the scrapes from CA than in those from the cervical canal and in the biopsy specimens. High-risk HPV types were also detected in the CA biopsy specimens, while the viral load was more often found to be statistically significantly higher in the samples of the cervical canal epithelium. The viral load in the scrapes from CA on the vulvar mucosa turned out to be statistically significantly higher than that in those on the vulvar skin.
Conclusion. CAs on the vulvar mucosa, even with small sizes, are a reservoir of HPV infection and have a more pronounced viral potential than those located on the skin, therefore CAs absolutely require timely and effective treatment.


polymerase chain reaction
condyloma acuminatum
human papillomavirus


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Received 11.01.2019

Accepted 22.02.2019

About the Authors

Apolikhina Inna A., MD, Professor, Head of aesthetical gynecology and rehabilitation department, Federal budget state institution V. I. Kulakov National Research Centre
for Obstetrics Gynecology and Perinatology, e-mail: apolikhina@inbox.ru, tel.+79854100811, ORCHID iD 0000-0002-4581-6295
Gasanova Gulnar F., graduent student of the Federal budget state institution “National Research Centre for Obstetrics Gynecology and Perinatology n. a. V. I. Kulakov”, e-mail: ice8507@rambler.ru, tel.+79256366822
Trofimov Dmitriy Y., MD, Professor, Head of clinical and molecular genetics Department of V. I. Kulakov Russian National Medical Research Centre for Obstetrics Gynecology and Perinatology, e-mail: d_trofimov@oparina4.ru
Donnikov Andrey E., PhD, Head of Laboratory of molecular-genetic methodsof V. I. Kulakov Russian National Medical Research Centre for Obstetrics Gynecology and Perinatology, e-mail: a_donnikov@oparina4.ru

For citation: Apolikhina I.A., Gasanova G.F., Trofimov D.M., Donnikov A.E. Diagnosis of vulvar condyloma acuminatum: clinical and molecular genetic aspects.
Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2019;(8):112-18 (in Russian)
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