Nutritional quality of women based on the results of their survey and assessment of the impact of supplemental vitamin and micronutrient intake during preconception and early pregnancy
Kravchenko E.N., Novitskaya E.L., Rozhkova L.Yu., Mamedova A.A., Turenko M.Yu.
Objective: To study the impact of a vitamin-mineral complex (VMC) supplement Premama Duo on general well-being, sleep quality, and the condition of the skin, hair, and nails in women at the preconception stage.
Materials and methods: This was a prospective observation of 250 women; the main group included 125 women at the preconception stage, who underwent a questionnaire survey and received VMC Premama Duo. The comparison group consisted of women who were registered for an unplanned pregnancy.
Results: Most women had factors contributing to hypopolyvitaminosis: body weight deficiency was in 23/250 (9.2%) of those examined, overweight and obesity were in 80/250 (32.0%). Gastrointestinal diseases were noted in 74/250 (29.6%) women and endocrine diseases in 17/250 (6.8%) women. It was found that 165/250 (66%) women regularly include meat in their diet, fruits and vegetables 153/250 (61.2%), fish and seafood 100/250 (40%), dairy products 142/250 (56.8%), whole grain carbohydrate food 61/250 (24.4%). Only 61/250 (24.4%) women had a balanced diet, 189/250 (75.6%) had an unbalanced diet. Clinical manifestations of deficiency were experienced by 121/250 (48.4%) respondents before preconception preparation, and 26/250 (10.4%) after preparation with the use of VMC Premama Duo.
After pregnancy, women in the group with preconception preparation showed symptoms such as decreased appetite significantly less frequently, namely 25/125 (20%) vs. 89/125 (71.2%) in the comparison group, taste changes – 1/125 (0.8%) vs. 17/125 (13.6%) respectively, muscle pain, cramps – 2/125 (1.6%) vs. 28/125 (22.4%), decreased hemoglobin level – 3/125 (2.4%) vs. 26/125 (20.8%), latent iron deficiency – 4/125 (3.2%) vs. 32/125 (25.6%). Morning sickness was also less frequent in the group of patients who had preconception preparation and took Premama Duo, 6/125 (4.8%) vs. 48/125 (38.4%).
Conclusion: The administration of VMC Premama Duo compensates the increased need for vitamins and trace elements during the preconception stage and early pregnancy, thus improving the general condition of the woman.
Authors’ contributions: Kravchenko E.N. – developing the concept and design of the study; Novitskaya E.L., Rozhkova L.Yu. – collecting and processing the material, statistical processing of the data; Mamedova А.A., Turenko M.Yu. – collecting and processing the material, writing the text.
Conflicts of interest: The authors declare no possible conflicts of interest.
Funding: The study was conducted without sponsorship.
Ethical Approval: The study was approved by the Ethical Review Board of the City Clinical Perinatal Center, protocol No.4.
Patient Consent for Publication: The patients provided an informed consent for the use of medical data for the educational process and scientific activities without specifying personal data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Kravchenko E.N., Novitskaya E.L., Rozhkova L.Yu., Mamedova A.A., Turenko M.Yu.
Nutritional quality of women based on the results of their survey and assessment of the impact of
supplemental vitamin and micronutrient intake during preconception and early pregnancy.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (11): 173-184 (in Russian)
https://dx.doi.org/10.18565/aig.2024.276
Keywords
References
- Cortés-Albornoz M.C., García-Guáqueta D.P., Velez-van-Meerbeke A., Talero-Gutiérrez C. Maternal nutrition and neurodevelopment: a scoping review. Nutrients. 2021; 13(10): 3530. https://dx.doi.org/10.3390/nu13103530.
- Лиманова О.А., Торшин И.Ю., Сардарян И.С., Калачева А.Г., Hababpashev A., Karpuchin D., Kudrin A., Юдина Н.В., Егорова Е.Ю., Белинская А.Ю., Гришина Т.Р., Громов А.Н., Федотова Л.Э., Рудаков К.В., Громова О.А. Обеспеченность микронутриентами и женское здоровье: интеллектуальный анализ клинико-эпидемиологических данных. Вопросы гинекологии, акушерства и перинатологии. 2014; 13(2): 5-15. [Limanova O.A., Torshin I.Yu., Sardaryan I.S., Kalacheva A.G., Hababpashev A., Karpuchin D., Yudina N.V.,Egorova E.Yu., Belinskaya A.Yu., Grishina T.R., Gromov A.N., Fedotova L.E., Rudakov K.V., Gromova O.A. Micronutrient provision and women’s health: intellectual analysis of clinicoepidemiological data. Gynecology, Obstetrics and Perinatology. 2014; 13(2): 5-15. (in Russian)].
- Торшин И.Ю., Лиманова О.А., Громова О.А., Тетруашвили Н.К., Коденцова В.М., Малявская С.И., Гришина Т.Р., Калачева А.Г., Мозговая Е.В., Захарова И.Н., Галустян А.Н., Семенов В.А., Громов А.Н., Лебедев А.В., Керимкулова Н.В., Лапочкина Н.П., Никифорова Н.В., Назаренко О.А., Богачева Т.Е., Федотова Л.Э., Гоголева И.В., Жидоморов Н.Ю., Фролова Д.Е., Рубашкина А.Н., Назаренко А.Г., Серов В.Н. Метрический анализ данных по взаимосвязям между показателями микронутриентной обеспеченности и состоянием здоровья женщин 18-45 лет. Медицинский алфавит. 2018; 21(2): 6-19.[Torshin I.Yu., Limanova O.A., Gromova O.A., Tetruashvili N.K., Kodentsova V.M., Malyavskaya S.I., Grishina T.R., Kalachyova A.G., Mozgovaya E.V., Zakharova I.N., Galustyan A.N., Semyonov V.A., Gromov A.N., Lebedev A.V., Kerimkulova N.V., Lapochkina N.P., Nikiforova N.V., Nazarenko O.A., Bogachyova T.E., Fedotova L.E., Gogoleva I.V., Zhidomorov N.Yu., Frolova D.E., Rubashkina A.N., Nazarenko A.G., Serov V.N. Metric analysis of data on relationship between indicators of micronutrient provision and state of health of women aged 18–45 years. Medical Alphabet. 2018; 21(2): 6-19.(in Russian)].
- Громова О.А., Торшин И.Ю. Микронутриенты и репродуктивное здоровье. Руководство. 2-е изд. М.: ГЭОТАР-Медиа; 2022. 832с. [Gromova O.A., Torshin I.Yu. Micronutrients and reproductive health. Guidance. 2nd ed. Moscow: GEOTAR-Media; 2022. 832р. (in Russian)].
- Gernand A.D., Schulze K.J., Stewart C.P., West K.P., Christian P. Micronutrient deficiencies in pregnancy worldwide: health effects and prevention. Nat. Rev. Endocrinol. 2016; 12(5): 274-89. https://dx.doi.org/10.1038/nrendo.2016.37.
- Schwarzenberg S.J., Georgieff M.K.; Committee on Nutrition. Advocacy for improving nutrition in the first 1000 days to support childhood development and adult health. Pediatrics. 2018; 141(2): e20173716. https://dx.doi.org/10.1542/peds.2017-3716.
- Randel A. Interpregnancy care: Guidelines from ACOG and SMFM. Am. Fam. Physician. 2019; 100(2): 121-3.
- Stephenson J., Heslehurst N., Hall J., Schoenaker D.A., Hutchinson J., Cade J.E. et al. Before the beginning: nutrition and lifestyle in the preconception period and its importance for future health. Lancet. 2018; 391(10132): 1830-41. https://dx.doi.org/10.1016/S0140-6736(18)30311-8.
- Douglas Wilson R., Van Mieghem T., Langlois S., Church P. Guideline No. 410: prevention, screening, diagnosis, and pregnancy management for fetal neural tube defects. J. Obstet. Gynaecol. Can. 2021; 43(1): 124-139.e8. https://dx.doi.org/10.1016/j.jogc.2020.11.003.
- Mousa A., Naqash A., Lim S. Macronutrient and micronutrient intake during pregnancy: an overview of recent evidence. Nutrients. 2019; 11(2) 443. https://dx.doi.org/10.3390/nu11020443.
- WHO. WHO Recommendations on Antenatal Care for a Positive Pregnancy Experience. Geneva: World Health Organization; 2016. 152 p.
- Федеральная служба государственной статистики. Российский статистический ежегодник. М.: Росстат; 2021. 692 с. [Federal State Statistics Service. Russian statistical yearbook. Moscow: Rosstat; 2021. 692 p.(in Russian)].
- Santander Ballestín S., Giménez Campos M.I., Ballestín Ballestín J., Luesma Bartolomé M.J. Is supplementation with micronutrients still necessary during pregnancy? A review. Nutrients. 2021; 13(9): 31-4. https://dx.doi.org/10.3390/nu13093134.
- WHO. Guideline: Daily Iron Supplementation in Adult Women and Adolescent Girls. Geneva: World Health Organization; 2016. 26 p.
- van der Pligt P., Willcox J., Szymlek-Gay E.A., Murray E., Worsley A., Daly R.M. Associations of maternal vitamin d deficiency with pregnancy and neonatal complications in developing countries: a systematic review. Nutrients. 2018; 10(5): 640. https://dx.doi.org/10.3390/nu10050640.
- Palacios C., Kostiuk L.K., Peña-Rosas J.P. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst. Rev. 2019; 7(7): CD008873. https://dx.doi.org/10.1002/14651858.CD008873.pub4.
- Пигарова Е.А., Рожинская Л.Я., Белая Ж.Е. и др. Клинические рекомендации Российской ассоциации эндокринологов по диагностике, лечению и профилактике дефицита витамина D у взрослых. Проблемы эндокринологии. 2016; 62(4): 60-1. [Pigarova E.A., Rozhinskaya L.Ia., Belaia Zh.E. et al. Russian Association of Endocrinologists recommendations for diagnosis, treatment and prevention of vitamin D deficiency in adults. Problems of Endocrinology. 2016; 62(4): 60-1. (in Russian)]. https://dx.doi.org/10.14341/probl201662460-84.
- WHO. Guideline: Calcium Supplementation in Pregnant Women. Geneva: World Health Organization; 2013.
- Тютюнник В.Л., Кан Н.Е., Ломова Н.А., Климанцев И.В. Вклад Омега-3 в микронутриентную поддержку в период беременности. РМЖ. 2017; 15: 1087-91. [Tyutyunnik V.L., Kan N.E., Lomova N.A., Klimantsev I.V. The role of Omega-3 fatty acids and micro nutrient support in the pregnancy period. RMJ. 2017; 15: 1087-91. (in Russian)].
- Методические рекомендации MP 2.3.1.0253-21 «Нормы физиологических потребностей в энергии и пищевых веществах для различных групп населения Российской Федерации» (утв. Федеральной службой по надзору в сфере защиты прав потребителей и благополучия человека 22 июля 2021 г.). М.; 2021. [Methodological recommendations MP 2.3.1.0253-21 "Norms of physiological needs for energy and food substances for various groups of the population of the Russian Federation" (approved by Federal Service for Supervision of Consumer Rights Protection and Human Welfare July 22, 2021). Moscow; 2021. (in Russian)].
- Междисциплинарная ассоциация специалистов репродуктивной медицины (МАРС). Прегравидарная подготовка. Клинический протокол. Версия 2.0. М.: StatusPraesens; 2020. 128 с. [Interdisciplinary Association of Reproductive Medicine Specialists. Pregravid preparation. Clinical protocol. Version 2.0. Мoscow: StatusPraesens; 2020. 128 p.(in Russian)].
- Инструкция к БАД «ПреМама Дуо». Рег. № RU.77.99.88.003.R.000523.03.23 от 2023-03-01. Доступно по: https://www.rlsnet.ru/baa/premama-duo-premama-duo-88258[Instructions for the Premama Duo dietary supplement. Reg. No. RU.77.99.88.003.R.000523.03.23 dated 2023-03-01. Available at: https://www.rlsnet.ru/baa/premama-duo-premama-duo-88258 (in Russian)].
- Tsoi K.Y., Chan R.S.M., Li L.S., McAuliffe F.M., Hanson M.A., Tam W.H. et al. Evaluation of dietary pattern in early pregnancy using the FIGO Nutrition Checklist compared to a food frequency questionnaire. Int. J. Gynecol. Obstet. 2020; 151 Suppl 1(Suppl 1): 37-44. https://dx.doi.org/10.1002/ijgo.13324.
- Серов В.Н., Артымук Н.В., Базина М.И., Баранов И.И., Башмакова Н.В. Габидуллина Р.И., Дубровина С.О., Зароченцева Н.В., Коган И.Ю., Максимова Ю.В., Мингалева Н.В., Серова О.Ф., Спиридонова Н.В., Тетруашвили Н.К., Ярмолинская М.И. Обзор предложений к новой версии клинических рекомендаций «Нормальная беременность» в контексте данных доказательной медицины. Акушерство и гинекология: новости, мнения, обучение. 2022; 10(4): 38-52. [Serov V.N., Artymuk N.V., Bazina M.I., Baranov I.I., Bashmakova N.V. Gabidullina R.I., Dubrovina S.O., Zarochentseva N.V., Kogan I.Yu., Maksimova Yu.V., Mingaleva N.V., Serova O.F., Spiridonova N.V., Tetruashvili N.K., Yarmolinskaya M.I. Review of proposals for the new clinical practice guidelines “Normal pregnancy” in context of evidence-based medicine data. Obstetrics and Gynecology: News, Opinions, Training. 2022; 10(4): 38-52. (in Russian)]. https://dx.doi.org/10.33029/2303-9698-2022-10-4-38-52.
- Ордиянц И.М., Молчанова О.К., Газарян Л.Г. Питание беременных с позиций доказательной медицины. StatusPraesens. Гинекология, акушерство, бесплодный брак. 2023; 4(100): 78-82. [Ordiyants I.M., Molchanova O.K., Ghazaryan L.G. Nutrition for pregnant women from the perspective of evidence-based medicine. StatusPraesens. Gynecology, obstetrics, infertile marriage. 2023; 4(100): 78-82.(in Russian)].
- WHO. WHO Antenatal Care Recommendations for a Positive Pregnancy Experience: Nutritional Interventions Update: Multiple Micronutrient Supplements During Pregnancy. Geneva: World Health Organization; 2020.
- Wolf H.T., Hegaard H.K., Huusom L.D., Pinborg A.B. Multivitamin use and adverse birth outcomes in high-income countries: a systematic review and meta-analysis. Am. J. Obstet. Gynecol. 2017; 217(4): 404.e1-e30. https://dx.doi.org/10.1016/j.ajog.2017.03.029.
- Громова О.А., Торшин И.Ю., Тетруашвили Н.К., Гоголева И.В. Систематический анализ фармакологических свойств протеин сукцинилата железа. Эффективная фармакотерапия. 2018; 13: 20-9. [Gromova O.A., Torshin I.Yu., Tetruashvili N.K., Gogoleva I.V. Systematic analysis of ferrous protein succinilate pharmacological properties. Effective Pharmacotherapy. 2018; (13): 20-9. (in Russian)].
- Ingle M.E., Bloom M.S., Parsons P.J., Steuerwald A.J., Kruger P., Fujimoto V.Y. Associations between IVF outcomes and essential trace elements measured in follicular fluid and urine: a pilot study. J. Assist. Reprod. Genet. 2017; 34(2): 253-61. https://dx.doi.org/10.1007/s10815-016- 0853-7.
- Yan Y., Xie C., Di S., Wang Z., Wu M., Li Y. et al. Supplemental folic acid and/or multivitamins in pregnancy is associated with a decreased risk of childhood and adolescent nasopharyngeal carcinoma. J. Dev. Orig. Health Dis. 2022; 13(5): 550-5. https://dx.doi.org/10.1017/S2040174421000635.
- Баранов И.И., Дмитриев М.Э., Попович Л.Д., Тетруашвили Н.К., Ярмолинская М.И., Зимоха А.Ю., Карташов Д.Д., Светличная С.В., Соколов К.А., Сулденко В.В. Обеспеченность микронутриентами женщин в РФ: влияние на течение беременности, перинатальные исходы и демографические показатели. Акушерство и гинекология: новости, мнения, обучение. 2021; 9(4): 44-51. [Baranov I.I., Dmitriev M.E., Popovich L.D., Tetruashvili N.K., Yarmolinskaya M.I.,Zimokha A.Yu., Kartashov D.D., Svetlichnaya S.V., Sokolov K.A., Suldenko V.V. Micronutrient provision of women in the Russian Federation: impact on the favorable course of pregnancy, perinatal outcomes and demographic indicators. Obstetrics and Gynecology: News, Opinions, Training. 2021; 9(4): 44-51. (in Russian)]. https://dx.doi.org/10.33029/2303-9698-2021-9-4-44-51.
- Макарова С.Г., Коденцова В.М., Ладодо О.Б., Продеус А.П., Басаргина М.А., Буцкая Т.В., Ясаков Д.С. Микронутриентный статус беременной женщины: риски, связанные с дефицитом, и методы коррекции. Акушерство и гинекология. 2020; 5: 156-64. [Makarova S.G., Kodentsova V.M., Ladodo O.B., Prodeus A.P., Basargina M.A., Butskaya T.V., Yasakov D.S. The micronutrient status of a pregnant woman: deficiency-associated risks and correction methods. Obstetrics and Gynecology. 2020; (5): 156-64 (in Russian)]. https://dx.doi.org/10.18565/aig.2020.5.156-64.
- Министерство здравоохранения Российской Федерации. Клинические рекомендации. Нормальная беременность. 2023. 90с. [Ministry of Health of the Russian Federation. Clinical Guidelines. Normal pregnancy. 2023. 90p. (in Russian)].
- Нормальная беременность (клинические рекомендации). Акушерство и гинекология: новости, мнения, обучение. 2020; 8(4): 48-78. [Physiological pregnancy (clinical guidelines). Obstetrics and Gynecology: News, Opinions, Training. 2020; 8(4): 48-78. (in Russian)].
- Баранов И.И. Индивидуальный подход к микронутриентной поддержке беременности. Акушерство и гинекология. 2020; 6 (Приложение): 14-6. [Baranov I.I. Individual approach to micronutrient support during pregnancy. Obstetrics and Gynecology. 2020; (6 Suppl.): 14-6. (in Russian)].
Received 01.11.2024
Accepted 27.11.2024
About the Authors
Elena N. Kravchenko, Dr. Med. Sci., Professor, Professor at the Department of Obstetrics and Gynecology No. 1, Omsk State Medical University, Ministry of Health of Russia, 644099, Russia, Omsk, Lenin str., 12, +7(3812)23-02-93, +7(913)620-81-62, kravchenko.en@mail.ru, https://orcid.org/0000-0001-9481-8812Elena L. Novitskaya, obstetrician-gynecologist of the highest qualification category, Head of Day Hospital No. 2, City Clinical Perinatal Center, 644010, Russia, Omsk, Mayakovsky str., 65/1, +7(3812)30-59-58, +7(905)922-27-62, fcabhm@bk.ru
Lydia Yu. Rozhkova, obstetrician-gynecologist of the first qualification category of specialized admission for miscarriage of Women’s Clinic No. 1, City Clinical Perinatal Center, 644069, Russia, Omsk, Herzen str., 69, +7(3812)94-01-40, +7(913)615-21-03, mamalida72@mail.ru
Aigyun A. Mamedova, obstetrician-gynecologist at Day Hospital No. 1, City Clinical Perinatal Center, 644069, Russia, Omsk, Herzen str., 69, +7(3812)94-01-47,
+7(908)116-12-42, mamedova-55@mail.ru
Marina Yu. Turenko, obstetrician-gynecologist of Day Hospital No. 1, City Clinical Perinatal Center, 644069, Russia, Omsk, Herzen str., 69, +7(3812)94-01-47,
+7(950)335-76-16, akuweronkolog@mail.ru
Corresponding author: Elena N. Kravchenko, kravchenko.en@mail.ru