The diagnostic role of microRNAs as biological markers of external (retrocervical) endometriosis

Almova I.K., Bobrov M.Yu., Chuprynin V.D., Khilkevich E.G., Chursin V.V., Melnikov M.V., Buralkina N.A., Veredchenko A.V.

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia
Objective. To analyze the data available in the current literature on the role of microRNAs as biological markers of external genital endometriosis.
Material and methods. The review includes the data of foreign and Russian authors, which have been found in PubMed, by using the key words: biomarkers of endometriosis; microRNAs and endometriosis; and biomarkers of external genital endometriosis. The search depth was 5 years.
Results. The differential expression of microRNAs in the eutopic and ectopic endometrium may suggest that microRNAs can play an important role in the development of endometrioid lesions. It is proven that miRNAs are active regulators of gene expression in endometriosis and associated reproductive dysfunctions. Detection of circulating miRNAs in plasma and other biological fluids in terms of their relative stability increases the likelihood that they may be investigated and proposed as non-invasive biomarkers for the diagnosis of endometriosis. Development of new exposure methods that can block the expression or mimic the function of miRNAs can represent new facets of treatment and prevention of a disease recurrence.
Conclusion. The investigations confirm the prospects and relevance of studying the role of microRNAs as diagnostic markers of external genital endometriosis. The development of non-invasive biomarkers will be able to substantially reduce the time of diagnosis of external genital endometriosis, followed by timely treatment.

Keywords

biomarkers
microRNA
endometriosis
eutopic and ectopic endometrium
gene expression
infertility
pelvic pain

Supplementary Materials

  1. Table 1. Comparison of microRNA expression characteristics in foci of endometriosis and control groups [0 1]
  2. Table 2. microRNAs differentially expressed in the lesions compared with EGE eutopic endometrium [0 1]

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Received 13.03.2017

Accepted 28.04.2017

About the Authors

Almova Indira K., postgraduate student of the Surgical Department, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79054357317. E-mail: www.gold11@mail.ru
Bobrov Mikhail Yu., Ph.D., Head of the Laboratory of Molecular Pathophysiology, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79032518677. E-mail: mbobr@mail.ru
Chuprynin Vladimir Dmitrievich, PhD, Head of the Department of General Surgery, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954383575. E-mail: v_chuprynin@oparina4.ru
Khilkevich Elena Grigorevna, leading researcher of General Surgery, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954387783. E-mail: e_khilkevich@oparina4.ru
Chursin Vyacheslav Vladimorovich, doctor surgeon of General Surgery, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954387833. E-mail:v_chursen@oparina4.ru
Melnikov Mikhail Viktorovich, Candidate of Medical Sciences, Head in Clinical Work, Department of Surgery, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954387833
Buralkina Natalya Aleksandrovna, doctor of Medical Sciences, Senior Researcher, the second gynecological department, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954387833. E-mail: n_buralkina@oparina4.ru
Veredchenko Aleksandr Viktorovich, candidate of medical sciences, doctor surgeon of General Surgery, Research Center of Obstetrics, Gynecology, and Perinatology,
Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954387833. E-mail: a_veredchenko@oparina4.ru

For citations: Almova I.K., Bobrov M.Yu., Chuprynin V.D., Khilkevich E.G., Chursin V.V., Melnikov M.V., Buralkina N.A., Veredchenko A.V. The diagnostic role of microRNAs as biological markers of external (retrocervical) endometriosis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (8): 34-40. (in Russian)
http://dx.doi.org/10.18565/aig.2017.8.34-40

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