CLINICAL FEATURES OF PATIENTS WITH HORMONE-DEPENDENT CONDITIONS AND MAGNESIUM DEFICIENCY
Objective. To assess the profile of female outpatients with various hormone-dependent conditions (HDCs) and magnesium deficiency (MD); to evaluate the clinical efficacy of magnesium citrate + pyridoxine hydrochloride (Magne B6 forte) in routine practice.Makatsaria A.D., Dadak C., Bitsadze V.O., Solopova A.G., Khamani N.M.
Subjects and methods. This was a multicenter observational study assessing the profile of 18-60-year-old female outpatients (n = 11,424) with HDCs (MD was estimated using the plasma Mg levels (bone mineral density (BMD) ≤ 0.8 mmol/l and/or the Mood Disorder Questionnaire (MDQ). The clinical efficacy of Magne B6 forte (BMD, the severity of symptoms, quality of life), safety profile, and therapy adherence was evaluated in women who used the drug (n = 2,142).
Results. The prevalence of MD ranged from 47.7% of the women receiving hormonal contraception to 66.4% of those with osteoporosis. After a month of taking Magne B6 forte, there was an increase in BMD, a reduction in the symptoms potentially related to MD, and an improvement in quality of life. No adverse events were recorded.
Conclusion. The prevalence of MD was shown to be high in women with HDCs. Magne B6 forte was effective in compensating for MD; there was a high therapy adherence and a favorable safety profile.
Keywords
magnesium deficiency
hormone-dependent conditions
Magne B6 forte
osteoporosis
premenstrual syndrome
climacteric syndrome
menopausal hormone therapy
hormonal contraception
References
1. Gromova O.A. Magnesium and pyridoxine: the basis of knowledge. Moscow; 2006. 176c. (in Russian)
2. Rude R.K., Gruber H.E. Magnesium deficiency and osteoporosis: animal and human observations. J. Nutr. Biochem. 2004; 15: 710-6.
3. Sarrafzadegan N., Khosravi-Boroujeni H., Lotfizadeh M., Pourmogaddas A., Salehi-Abargouei A. Magnesium status and the metabolic syndrome: A systematic review and meta-analysis. Nutrition. 2016; 32(4): 409-17.
4. Qu X., Jin F., Hao Y., Li H., Tang T., Wang H. et al. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies. PLoS One. 2013; 8(3): e57720. doi: 10.1371/journal.pone.0057720.
5. Martynova A.I., Nechaeva G.I. National guidelines for the diagnosis, treatment and rehabilitation of patients with connective tissue dysplasia. Moscow: Bionika Media; 2016. 80p. (in Russian)
6. Rubenowitz E., Molin I., Axelsson G., Rylander R. Magnesium in drinking water in relation to morbidity and mortality from acute myocardial infarction. Epidemiology. 2000; 11(4): 416-21.
7. Luoma H. Risk of myocardial infarction in relation to magnesium and calcium concentrations in drinking water, with some aspects on the magnesium vs. fluoride interactions. In: Itokawa Y., J. Durlach J. eds. Magnesium in health and disease. John Libbey & Co Ltd.; 1989: 183-90.
8. Stanton M.F., Lowenstein F.W. Serum magnesium in women during pregnancy, while taking contraceptives, and after menopause. J. Am. Coll. Nutr. 1987; 6(4): 313-9.
9. López-González B., Molina-López J., Florea D.I., Quintero-Osso B., Pérez de la Cruz A., Planells del Pozo E.M. Association between magnesium-deficient status and anthropometric and clinical-nutritional parameters in posmenopausal women. Nutr. Hosp. 2014; 29(3): 658-64. doi: 10.3305/nh.2014.29.3.7198.
10. Aydin H., Deyneli O., Yavuz D., Gözü H., Mutlu N., Kaygusuz I. et al. Short-term oral magnesium supplementation suppresses bone turnover in postmenopausal osteoporotic women. Biol. Trace Elem. Res. 2010; 133(2): 136-43. doi: 10.1007/s12011-009-8416-8.
11. Izmozherova N.V., Popov A.A., Fominyih M.I., Andreev A.I., Stryukov O.Yu., Tagil’tseva N.V., Gavrilova E.I. Magnesium deficiency in women in menopause. Klinicheskaya meditsina. 2007; 85(5): 62-4. (in Russian)
12. Farhangi M.A., Ostadrahimi A., Mahboob S. Serum calcium, magnesium, phosphorous and lipid profile in healthy Iranian premenopausal women. Biochem. Med. (Zagreb). 2011; 21(3): 312-2.
13. Unanyan A.L., Morozova V.D., Kossovich Yu.M., Kadyirova A.E., Makarova I.I. Premenstrual syndrome: issues of classification, diagnosis and treatment. Voprosyi ginekologii, akusherstva i perinatologii. 2013; 12(3): 51-6. (in Russian)
14. Mezhevitinova E.A., Akopyan A.N. Magnesium-deficient states in gynecological practice: clinical evaluation and methods of correction. Voprosyi ginekologii, akusherstva i perinatologii. 2007; 6(4): 91-9. (in Russian)
15. Smetnik V.P., Butareva L.B. Place of Magne B6 in the correction of psycho-vegetative disorders in women with menopausal syndrome in postmenopausal women. Farmateka. 2004; 15: 1-4. (in Russian)
16. Serov V.N., Baranov I.I., Blinov D.V., Zimovina U.V., Sandakova E.A., Ushakova T.I. Results of investigation of magnesium deficiency in patients with hormone-dependent diseases. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2015; (6): 91-7. (in Russian)
17. Makatsariya A.D., Bitsadze V.O., Hizroeva D.H., Dzhobava E.M. Prevalence of magnesium deficiency in the population of pregnant women observed in outpatient settings in antenatal clinics. Voprosyi ginekologii, akusherstva i perinatologii. 2012; 11(5): 25-35. (in Russian)
18. Slagle P. Magnificent magnesium. The Way Up Newsletter. Vol. 30, 08-15-01.
19. WHO short questionnaire for assessing the quality of life. The World Health Organization Quality of Life (WHOQOL) -BREF. WHO; 2004. (in Russian)
20. Gromova O.A., Kalacheva A.G., Torshin I.Yu., Rudakov K.V., Grustlivaya U.E., Yudina N.V. Magnesium deficiency is a reliable risk factor for comorbid conditions: the results of a large-scale screening of magnesium status in Russian regions. Farmateka. 2013; 6: 116-29. (in Russian)
21. Plenum of the Presidium of the Russian Society of Obstetricians and Gynecologists. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2015; (5): 113-5. (in Russian)
Received 10.02.2017
Accepted 17.02.2017
About the Authors
Alexander Makatsariya, MD, PhD Professor, Correspondent Member of the Russian Academy of Sciences, Head of the Department of Obstetrics and Gynecology of Medical Prophylaxis Faculty of I.M. Sechenov First Moscow State Medical University, Vice-President of Russian Association of Obstetricians and Gynaecologists.109004, Russia, Moscow, Zemlyanoi Val, 62. Tel.: +79037280897. E-mail: gemostasis@mail.ru
Christian Dadak, professor at the University Clinic of Obstetrics and Gynecology in Vienna; Head of the International Center for Postgraduate Education in Women’s Health. Tel.: +4314040029100; Fax: +4314040027750. E-mail: christian.dadak@meduniwien.ac.at
Viktoriya Bitsadze, MD, PhD, Professor of the Department of Obstetrics and Gynecology of Medical Prophylaxis Faculty of I.M. Sechenov First Moscow State Medical University. 109004, Russia, Moscow, Zemlyanoi Val, 62. Tel.: +79262313829. E-mail: vikabits@mail.ru
Solopova Alina Evgen’evna, Candidate of Medicine, assistant professor, Department of radiology and radiotherapy, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia. 119991, Russia, Moscow, Bolshaya Pirogovskaya str. 2, bld. 4. E-mail: dr.solopova@mail.ru
Hamani Nadin Moktarovna, Post-graduate student of the Department of Obstetrics and Gynecology of the Medical-Prophylactic Faculty I.M. Sechenov First Moscow
State Medical University, Ministry of Health of Russia. 119991, Russia, Moscow, Bolshaya Pirogovskaya str. 2, bld. 4. Tel.: +74957885840. E-mail: gemostasis@mail.ru
For citations: Makatsaria A.D., Dadak C., Bitsadze V.O., Solopova A.G., Khamani N.M. Clinical features of patients with hormone-dependent conditions and magnesium deficiency.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (5): 124-31. (in Russian)
http://dx.doi.org/10.18565/aig.2017.5.124-31
