Biomarkers in ovarian neoplasms: opportunities, limitations, and prospects for using in reproductive-aged women

Pavlovich S.V., Yurova M.V., Melkumyan A.G., Frankevich V.E., Chagovets V.V., Khabas G.N.

1) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia; 2) I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, Moscow, Russia
Ovarian proliferative processes are a serious problem for reproductive-aged women. The problems in the differential diagnosis of endometriosis, ovarian tumors and neoplasms are associated with erroneous treatment and poor prognosis. The data available in global literature on achievements in noninvasive diagnosis over 2010–2019 have been analyzed to compare the possibilities and limitations of studies of markers in biological fluids for ovarian diseases, in particular, for ovarian endometriosis.

Keywords

endometriosis
menstrual blood
ovarian neoplasms
ovarian cancer
biomarkers

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Received 30.09.2019

Accepted 04.10.2019

About the Authors

Stanislav V. Pavlovich, PhD, scientific secretary in Federal State Budget Institution “National Medical Research Center for Obstetrics, Gynecology and Perinatology named
after Academician V.I. Kulakov” Ministry of Health of Russia. Tel.: +7 (495)438-20-88. E-mail: s_pavlovich@oparina4.ru
117997, Russia, Moscow, Ac. Oparina 4.
Maria V. Yurova, Postgraduate student in Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University
of the Ministry of Health of the Russian Federation (Sechenov University), department of obstetrics, gynecology, perinatology and reproductive health; the Faculty of Higher Professional Training (Federal State Budget Institution “National Medical Research Center for Obstetrics, Gynecology and Perinatology named
after Academician V.I. Kulakov” Ministry of Health of Russia). Tel.: +7(495)438-20-88; https://orcid.org/0000-0002-0179-7635. E-mail: m_yurova@oparina4.ru
117997, Russia, Moscow, Ac. Oparina 4.
Arika.G. Melkumyan, postgraduate student, National Medical Research Center for Obstetrics, Gynecology and Perinatology of Ministry of Healthcare of Russian Federation; Tel.: +7(963)9633755, е-mail: dr.melkumyan@gmail.com
117997, Russia, Moscow, Ac. Oparina 4.
Vladimir E. Frankevich, PhD, Head of Department of Systems Biology in Reproduction, Federal State Budget Institution “National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov” Ministry of Health of Russia, Tel.: +7(495)438-0788-2198 e-mail: v_frankevich@oparina4.ru
117997, Russia, Moscow, Ac. Oparina 4.
Vitaliy V. Chagovets, PhD, Senior Researcher of the Laboratory of Proteomics and Metabolomics in Human Reproduction at the Department of Systems Biology in Federal State Budget Institution “National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov” Ministry of Health
of Russia. Tel. +7(926) 562-65-90. E-mail: vvchagovets@gmail.com
117997, Russia, Moscow, Ac. Oparina 4.
Grigory N. Khabas, Candidate of Medical Sciences, Head, Department of Innovative Oncology and Gynecology in Federal State Budget Institution “National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov” Ministry of Health of Russia.Tel.: +7(495)4387833. E-mail: g_khabas@oparina4.ru
117997, Russia, Moscow, Ac. Oparina Str. 4.

For citations: Pavlovich S.V., Yurova M.V., Melkumyan A.G., Frankevich V.E., Chagovets V.V., Khabas G.N.Biomarkers in ovarian neoplasms: opportunities, limitations, and prospects for using in reproductive-aged women.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2019; 11:65-73. (In Russian).
https://dx.doi.org/10.18565/aig.2019.11.65-73

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